Effects of clonidine and methylphenidate on family quality of life in attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

The aim of this study was to determine the effect on family quality of life (QOL) of clonidine (CLON) and methylphenidate (MPH), used alone and in combination, in treating attention-deficit/hyperactivity disorder (ADHD).

Methods

Two proxy QOL measures were used in a multicenter, double-blind, placebo-controlled 16-week trial of 122 children, ages 7-12 years, with ADHD. Children were randomized to one of four groups in which they received MPH, CLON, a combination of drugs, or placebo. QOL was measured with the Daily Hassles Scale and the Impact on Family Scale at baseline and at 16 weeks.

Results

In a general linear model repeated measures analysis, treatment groups improved over a 16-week period compared to placebo for Daily Hassles and Impact on Family, as

SUBMITTER: Cannon M 

PROVIDER: S-EPMC2830226 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature