Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease.

ABSTRACT:

Background

Late-onset Alzheimer disease (LOAD) is a common disorder with a substantial genetic component. We postulate that many disease susceptibility variants act by altering gene expression levels.

Methods

We measured messenger RNA (mRNA) expression levels of 12 LOAD candidate genes in the cerebella of 200 subjects with LOAD. Using the genotypes from our LOAD genome-wide association study for the cis-single nucleotide polymorphisms (SNPs) (n = 619) of these 12 LOAD candidate genes, we tested for associations with expression levels as endophenotypes. The strongest expression cis-SNP was tested for AD association in 7 independent case-control series (2,280 AD and 2,396 controls).

Results

We identified 3 SNPs that associated significantly with IDE (insulin degrading e

SUBMITTER: Zou F 

PROVIDER: S-EPMC2830916 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature