Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins.

ABSTRACT:

Background

Reproductive proteins are central to the continuation of all mammalian species. The evolution of these proteins has been greatly influenced by environmental pressures induced by pathogens, rival sperm, sexual selection and sexual conflict. Positive selection has been demonstrated in many of these proteins with particular focus on primate lineages. However, the mammalia are a diverse group in terms of mating habits, population sizes and germ line generation times. We have examined the selective pressures at work on a number of novel reproductive proteins across a wide variety of mammalia.

Results

We show that selective pressures on reproductive proteins are highly varied. Of the 10 genes analyzed in detail, all contain signatures of positive selection either across

SUBMITTER: Morgan CC 

PROVIDER: S-EPMC2830953 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature