Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish.

ABSTRACT:

Background

Immune challenge impacts behavior in many species. In mammals, this adaptive behavior is often manifested as an increase in sleep. Sleep has therefore been proposed to benefit the host by enhancing immune function and thereby overcome the challenge. To facilitate genetic studies on the relationship between sleep and immune function, we characterized the effect of the immune response on sleep in Drosophila melanogaster. Behavioral features of sleep as well as the innate immune response signaling pathways are well characterized in flies and are highly conserved in mammals.

Results

An immune response induced by infection with Gram-negative bacteria or by aseptic injury increased sleep in flies. The increase in sleep occurred during the morning hours after treatment a

SUBMITTER: Kuo TH 

PROVIDER: S-EPMC2831041 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature