Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro.

ABSTRACT:

Background

Neurite outgrowth is a key process during neuronal migration and differentiation. Complex intracellular signaling is involved in the initiation of neurite protrusion and subsequent elongation. Although, in general many constituents of the machinery involved in this multi-stage process are common for neurons in distinct brain areas, there are notable differences between specific neuronal subtypes.

Results

We analyzed key intracellular components of neurite outgrowth signaling in postnatally born subventricular zone (SVZ) neurons in vitro. We showed that inhibitors of PI3K, Akt1, PKCzeta and small GTPases significantly reduced neurite outgrowth. Transfection of SVZ-derived neurons with inactive forms of Rac1 or Cdc42 also decreased neurite length whereas transfectio

SUBMITTER: Khodosevich K 

PROVIDER: S-EPMC2831042 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature