Signal transduction networks in cancer: quantitative parameters influence network topology.

ABSTRACT: Networks of fixed topology are used to summarize the collective understanding of the flow of signaling information within a cell (i.e., canonical signaling networks). Moreover, these canonical signaling networks are used to interpret how observed oncogenic changes in protein activity or expression alter information flow in cancer cells. However, creating a novel branch within a signaling network (i.e., a noncanonical edge) provides a mechanism for a cell to acquire the hallmark characteristics of cancer. The objective of this study was to assess the existence of a noncanonical edge within a receptor tyrosine kinase (RTK) signaling network based upon variation in protein expression alone, using a mathematical model of the early signaling events associated with epidermal growth factor recept

SUBMITTER: Klinke DJ 

PROVIDER: S-EPMC2831142 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature