Hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma.

ABSTRACT: The inability to forecast outcomes for malignant mesothelioma prevents clinicians from providing aggressive multimodality therapy to the most appropriate individuals who may benefit from such an approach. We investigated whether specific microRNAs (miR) could segregate a largely surgically treated group of mesotheliomas into good or bad prognosis categories. A training set of 44 and a test set of 98 mesothelioma tumors were analyzed by a custom miR platform, along with 9 mesothelioma cell lines and 3 normal mesothelial lines. Functional implications as well as downstream targets of potential prognostic miRs were investigated. In both the training and test sets, hsa-miR-29c* was an independent prognostic factor for time to progression as well as survival after surgical cytoreduction. The mi

SUBMITTER: Pass HI 

PROVIDER: S-EPMC2831149 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature