Population-based family history-specific risks for colorectal cancer: a constellation approach.

ABSTRACT:

Background & aims

Colorectal cancer (CRC) risk estimates based on family history typically include only close relatives. We report familial relative risk (FRR) in probands with various combinations, or constellations, of affected relatives, extending to third-degree.

Methods

A population-based resource that includes a computerized genealogy linked to statewide cancer records was used to identify genetic relationships among CRC cases and their first-, second-, and third-degree relatives (FDRs, SDRs, and TDRs). FRRs were estimated by comparing the observed number of affected persons with a particular family history constellation to the expected number, based on cohort-specific CRC rates.

Results

A total of 2,327,327 persons included in > or =3 generation family historie

SUBMITTER: Taylor DP 

PROVIDER: S-EPMC2831153 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature