Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.

ABSTRACT:

Background & aims

Lack of detection technology for early pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. New strategies and biomarkers for early detection are sorely needed. In this study, we have conducted a prospective sample collection and retrospective blinded validation to evaluate the performance and translational utilities of salivary transcriptomic biomarkers for the noninvasive detection of resectable pancreatic cancer.

Methods

The Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Biomarkers discovered from the microarray study were subjected to clinical validation using an independent sample se

SUBMITTER: Zhang L 

PROVIDER: S-EPMC2831159 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature