Heritability of thromboxane A2 and prostaglandin E2 biosynthetic machinery in a Spanish population.

ABSTRACT:

Objective

Prostanoids play a critical role in clinical areas such as inflammation, thrombosis, immune response, and cancer. Although some studies suggest that there are genes that determine variability of some prostanoid-related phenotypes, the genetic influence on these traits has not been evaluated.

Methods and results

The relative contributions of genetic and environmental influences to the prostanoid biosynthetic pathway-related phenotypes, cyclooxygenase isoenzymes, microsomal-PGE-synthase-1 and TxA-synthase expression, and thromboxane-A(2) and prostaglandin-E(2) production by stimulated whole blood, were assessed in a sample of 308 individuals in 15 extended families. The effects of measured covariates (such as sex, age, and smoking), genes, and environmental variables

SUBMITTER: Vila L 

PROVIDER: S-EPMC2831176 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature