Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study.

ABSTRACT:

Background

Together with smoking, the lung function attained in early adulthood is one of the strongest predictors of chronic obstructive pulmonary disease. We aimed to investigate whether lung function in early adulthood is, in turn, affected by airway function measured shortly after birth.

Methods

Non-selected infants were enrolled at birth in the Tucson Children's Respiratory Study between 1980 and 1984. We measured maximal expiratory flows at functional residual capacity (Vmax(FRC)) in 169 of these infants by the chest compression technique at a mean of 2.3 months (SD 1.9). We also obtained measurements of lung function for 123 of these participants at least once at ages 11, 16, and 22 years. Indices were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC

SUBMITTER: Stern DA 

PROVIDER: S-EPMC2831283 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature