Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons.

ABSTRACT: Using a comparative genomics approach to reconstruct the fate of genomic regulatory blocks (GRBs) and identify exonic remnants that have survived the disappearance of their host genes after whole-genome duplication (WGD) in teleosts, we discover a set of 38 candidate cis-regulatory coding exons (RCEs) with predicted target genes. These elements demonstrate evolutionary separation of overlapping protein-coding and regulatory information after WGD in teleosts. We present evidence that the corresponding mammalian exons are still under both coding and non-coding selection pressure, are more conserved than other protein coding exons in the host gene and several control sets, and share key characteristics with highly conserved non-coding elements in the same regions. Their dual function is corro

SUBMITTER: Dong X 

PROVIDER: S-EPMC2831330 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature