Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.

ABSTRACT:

Purpose

Age-related cataract is a multi-factorial disease with a poorly understood etiology. Numerous studies provide evidence that the human eye lens has evolved specific regulatory and protective systems to ameliorate lens damage associated with cataract. Other studies suggest that the presence of cataract is associated with the altered expression of specific genes including metallothionein IIa, osteonectin, transglutaminase 2, betaig-h3, multiple ribosomal proteins, ADAM9, and protein phosphatase 2A. Here, we sought to identify further gene expression changes that are associated with cataract and to cluster the identified genes into specific biological pathways.

Methods

Oligonucleotide microarray hybridization was used to analyze the full complement of gene expression dif

SUBMITTER: Hawse JR 

PROVIDER: S-EPMC2831407 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature