Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study.

ABSTRACT:

Background

Carotid atherosclerosis is a known biomarker associated with future vascular disease. The risk associated with small, nonstenotic carotid plaques is less clear. The objective of this study was to examine the association between maximum carotid plaque thickness and risk of vascular events in an urban multiethnic cohort.

Methods

As part of the population-based Northern Manhattan Study, carotid plaque was analyzed among 2,189 subjects. Maximum carotid plaque thickness was evaluated at the cutoff level of 1.9 mm, a prespecified value of the 75th percentile of the plaque thickness distribution. The primary outcome measure was combined vascular events (ischemic stroke, myocardial infarction, or vascular death).

Results

Carotid plaque was present in 1,263 (58%) su

SUBMITTER: Rundek T 

PROVIDER: S-EPMC2831775 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature