Anti-tetherin activities in Vpu-expressing primate lentiviruses.

ABSTRACT:

Background

The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells. However, tetherin restriction is also counteracted by primate lentiviruses that do not express a Vpu protein, where anti-tetherin functions are provided by either the Env protein (HIV-2, SIVtan) or the Nef protein (SIVsm/mac and SIVagm). Within the primate lentiviruses, Vpu is also present in the genomes of SIVcpz and certain SIVsyk viruses. We asked whether, in these viruses, anti-tetherin activity was always a property of Vpu, or if it had selectively evolved in HIV-1 to perform this function.

Results

We found that despite the close relatedness of HIV-1 and SIVcpz, the chimpanzee

SUBMITTER: Yang SJ 

PROVIDER: S-EPMC2831821 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature