GSK3 and p53 - is there a link in Alzheimer's disease?

ABSTRACT:

Background

Recent evidence suggests that glycogen synthase kinase-3beta (GSK3beta) is implicated in both sporadic and familial forms of Alzheimer's disease. The transcription factor, p53 also plays a role and has been linked to an increase in tau hyperphosphorylation although the effect is indirect. There is also evidence that GSK3beta and p53 interact and that the activity of both proteins is increased as a result of this interaction. Under normal cellular conditions, p53 is kept at low levels by Mdm2 but when cells are stressed, p53 is stabilised and may then interact with GSK3beta. We propose that this interaction has an important contribution to cellular outcomes and to test this hypothesis we developed a stochastic simulation model.

Results

The model predicts that high

SUBMITTER: Proctor CJ 

PROVIDER: S-EPMC2831894 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature