Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice.

ABSTRACT:

Background

Chronic inflammation is a characteristic feature of diabetic cutaneous wounds. We sought to delineate novel mechanisms involved in the impairment of resolution of inflammation in diabetic cutaneous wounds. At the wound-site, efficient dead cell clearance (efferocytosis) is a pre-requisite for the timely resolution of inflammation and successful healing.

Methodology/principal findings

Macrophages isolated from wounds of diabetic mice showed significant impairment in efferocytosis. Impaired efferocytosis was associated with significantly higher burden of apoptotic cells in wound tissue as well as higher expression of pro-inflammatory and lower expression of anti-inflammatory cytokines. Observations related to apoptotic cell load at the wound site in mice were valida

SUBMITTER: Khanna S 

PROVIDER: S-EPMC2832020 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature