Iodine/palladium approaches to the synthesis of polyheterocyclic compounds.

ABSTRACT: A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I(2) or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of linked and fused PHCs.

SUBMITTER: Mehta S 

PROVIDER: S-EPMC2832103 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature