Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response.

ABSTRACT: Poliovirus is an enteric virus that rarely invades the human central nervous system (CNS). To identify barriers limiting poliovirus spread from the periphery to CNS, we monitored trafficking of 10 marked viruses. After oral inoculation of susceptible mice, poliovirus was present in peripheral neurons, including vagus and sciatic nerves. To model viral trafficking in peripheral neurons, we intramuscularly injected mice with poliovirus, which follows a muscle-sciatic nerve-spinal cord-brain route. Only 20% of the poliovirus population successfully moved from muscle to brain, and three barriers limiting viral trafficking were identified. First, using light-sensitive viruses, we found limited viral replication in peripheral neurons. Second, retrograde axonal transport of poliovirus in peripher

SUBMITTER: Lancaster KZ 

PROVIDER: S-EPMC2832671 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature