Correcting population stratification in genetic association studies using a phylogenetic approach.

ABSTRACT:

Motivation

The rapid development of genotyping technology and extensive cataloguing of single nucleotide polymorphisms (SNPs) across the human genome have made genetic association studies the mainstream for gene mapping of complex human diseases. For many diseases, the most practical approach is the population-based design with unrelated individuals. Although having the advantages of easier sample collection and greater power than family-based designs, unrecognized population stratification in the study samples can lead to both false-positive and false-negative findings and might obscure the true association signals if not appropriately corrected.

Methods

We report PHYLOSTRAT, a new method that corrects for population stratification by combining phylogeny constructed from SN

SUBMITTER: Li M 

PROVIDER: S-EPMC2832820 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature