Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes.

ABSTRACT:

Purpose of review

The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D).

Recent findings

Several studies reported that dietary factors related to carbohydrate quality and quantity, such as whole grains and glycemic load, might interact with transcription factor 7-like 2 variants in relation to T2D risk. The genetic predisposition defined by the combination of 10 established T2D risk alleles was found to modulate the association between Western dietary pattern (high intakes of red meat, processed meat, and low fiber) and T2D; a stronger association was observed in those with a high-risk genetic profile. Variants in genes HHEX, CDKN2A/2B, JAZF1, and IGF2

SUBMITTER: Qi L 

PROVIDER: S-EPMC2833314 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature