Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis.

ABSTRACT: Putative virulence genes of Helicobacter pylori are generally classified into three categories: strain-specific genes, phase-variable genes and genes with variable structures/genotypes. Among these, there has recently been considerable interest in strain-specific genes found outside of the cag pathogenicity island, especially genes in the plasticity regions. Nearly half of the strain-specific genes of H. pylori are located in the plasticity regions in strains 26695 and J99. Strain HPAG1, however, seems to lack a typical plasticity region; instead it has 43 HPAG1-specific genes which are either undetectable or incompletely represented in the genomes of strains 26695 and J99. Recent studies showed that certain genes or combination of genes in this region may play important roles in the patho

SUBMITTER: Yamaoka Y 

PROVIDER: S-EPMC2833349 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature