Chemical rescue of protein tyrosine phosphatase activity.

ABSTRACT: We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.

SUBMITTER: Chen VL 

PROVIDER: S-EPMC2834275 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature