Proteome changes of Caenorhabditis elegans upon a Staphylococcus aureus infection.

ABSTRACT:

Background

The success of invertebrates throughout evolution is an excellent illustration of the efficiency of their defence strategies. Caenorhabditis elegans has proven to be an appropriate model for transcriptome studies of host-pathogen interactions. The aim of this paper is to complement this knowledge by investigating the worm's response to a Staphylococcus aureus infection through a 2-dimensional differential proteomics approach.

Results

Different types of growth media in combination with either E. coli OP50 or Staphylococcus aureus were tested for an effect on the worm's lifespan. LB agar was chosen and C. elegans samples were collected 1 h, 4 h, 8 h and 24 h post S. aureus infection or E. coli incubation. Proteomics analyses resulted in the identification of 130 spo

SUBMITTER: Bogaerts A 

PROVIDER: S-EPMC2834640 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature