Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia.

ABSTRACT:

Background

Enlarged ventricles and reduced hippocampal volume are consistently found in patients with first-episode schizophrenia. Studies investigating brain structure in antipsychotic-naive patients have generally focused on the striatum. In this study, we examined whether ventricular enlargement and hippocampal and caudate volume reductions are morphological traits of antipsychotic-naive first-episode schizophrenia.

Methods

We obtained high-resolution 3-dimensional T1-weighted magnetic resonance imaging scans for 38 antipsychotic-naive first-episode schizophrenia patients and 43 matched healthy controls by use of a 3-T scanner. We warped the brain images to each other by use of a high-dimensional intersubject registration algorithm. We performed voxel-wise group compariso

SUBMITTER: Ebdrup BH 

PROVIDER: S-EPMC2834791 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature