Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan BA
PROVIDER: S-EPMC2834884 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20091130 1
Certain glycolipid Ags for Valpha14i NKT cells can direct the overall cytokine balance of the immune response. Th2-biasing OCH has a lower TCR avidity than the most potent agonist known, alpha-galactosylceramide. Although the CD1d-exposed portions of OCH and alpha-galactosylceramide are identical, structural analysis indicates that there are subtle CD1d conformational differences due to differences in the buried lipid portion of these two Ags, likely accounting for the difference in antigenic po ...[more]