Genetic variants associated with complex human diseases show wide variation across multiple populations.

ABSTRACT:

Background

The wide use of genome wide association studies (GWAS) has led to the successful identification of multiple genetic susceptibility variants to several complex human diseases. Given the limited amount of data on genetic variation at these loci in populations of non-European origin, we investigated population variation among 11 population groups for loci showing strong and consistent association from GWAS with several complex human diseases.

Methods

Data from the International HapMap Project Phase 3, comprising 11 population groups, were used to estimate allele frequencies at loci showing strong and consistent association from GWAS with any of 26 complex human diseases and traits. Allele frequency summary statistics and F(ST) at each locus were used to estimate popu

SUBMITTER: Adeyemo A 

PROVIDER: S-EPMC2835382 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature