Inference of the haplotype effect in a matched case-control study using unphased genotype data.

ABSTRACT: Typically locus specific genotype data do not contain information regarding the gametic phase of haplotypes, especially when an individual is heterozygous at more than one locus among a large number of linked polymorphic loci. Thus, studying disease-haplotype association using unphased genotype data is essentially a problem of handling a missing covariate in a case-control design. There are several methods for estimating a disease-haplotype association parameter in a matched case-control study. Here we propose a conditional likelihood approach for inference regarding the disease-haplotype association using unphased genotype data arising from a matched case-control study design. The proposed method relies on a logistic disease risk model and a Hardy-Weinberg equilibrium (HWE) among the cont

SUBMITTER: Sinha S 

PROVIDER: S-EPMC2835450 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature