Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis.

ABSTRACT:

Background

Previous meta-analyses of treatments for pulmonary arterial hypertension (PAH) have not shown mortality benefit from any individual class of medication.

Methods

MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from inception through November 2009 for randomized trials that evaluated any pharmacotherapy in the treatment of PAH. Reference lists from included articles and recent review articles were also searched. Analysis included randomized placebo controlled trials of at least eight weeks duration and studies comparing intravenous medication to an unblinded control group.

Results

1541 unique studies were identified and twenty-four articles with 3758 patients were included in the meta-analysis. Studies were reviewed and d

SUBMITTER: Ryerson CJ 

PROVIDER: S-EPMC2835653 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature