MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori.

ABSTRACT:

Background

MicroRNAs (miRNAs) repress target genes at the post-transcriptional level, and function in the development and cell-lineage pathways of host species. Tissue-specific expression of miRNAs is highly relevant to their physiological roles in the corresponding tissues. However, to date, few miRNAs have been spatially identified in the silkworm.

Results

We establish for the first time the spatial expression patterns of nearly 100 miRNAs in multiple normal tissues (organs) of Bombyx mori females and males using microarray and Northern-blotting analyses. In all, only 10 miRNAs were universally distributed (including bmo-let-7 and bmo-bantam), while the majority were expressed exclusively or preferentially in specific tissue types (e.g., bmo-miR-275 and bmo-miR-1). Additio

SUBMITTER: Liu S 

PROVIDER: S-EPMC2835664 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature