Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly.

ABSTRACT: Macrophages (M phi) are activated by IFN gamma and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFN gamma-induced M phi differentiation. We found that MCMV infection inhibited IFN gamma regulation of many genes in M phi. MCMV infection blocked IFN gamma responses at the level of transcription without blocking Janus kinase/signal transducer and activator of transcription pathway activation and targeted IFN response factor 1- and class II transactivator-dependent and independent promoters. MCMV did not alter basal transcription from IFN gamma-responsive promoters and left the majority of cellular transcripts unchanged even after 48 h of infection. The effects of MCMV infection were specific to chromosomal ra

SUBMITTER: Popkin DL 

PROVIDER: S-EPMC283588 | biostudies-literature | 2003 Nov

REPOSITORIES: biostudies-literature