Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.

ABSTRACT: Multicellular organisms are continuously exposed to many different pathogens. Because different classes of pathogens require different types of immune responses, understanding how an ongoing immune response to one type of infection affects the host's ability to respond to another pathogen is essential for a complete understanding of host-pathogen interactions. Here, we used a mouse model of coinfection to gain insight into the effect of respiratory influenza virus infection on a subsequent systemic bacterial infection. We found that influenza infection triggered a generalized stress response leading to a sustained increase in serum glucocorticoid levels, resulting in a systemic suppression of immune responses. However, virus-induced glucocorticoid production was necessary to control the in

SUBMITTER: Jamieson AM 

PROVIDER: S-EPMC2836270 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature