Integrative pathway-centric modeling of ventricular dysfunction after myocardial infarction.

ABSTRACT:

Background

A significant proportion of myocardial infarction (MI) patients undergo complex, coordinated perturbations at the molecular level that may eventually drive the occurrence of ventricular dysfunction and heart failure. Despite advances in the elucidation of key processes implicated in this condition, traditional methods relying on gene expression data and the identification of individual biomarkers in isolation pose major limitations not only for improving prediction power, but also for model interpretability. Mechanisms underlying clinical responses after MI remain elusive and there is no biomarker with the capacity to accurately predict ventricular dysfunction after MI. This calls for the exploration of system-level modeling of ventricular dysfunction in post-MI patients

SUBMITTER: Azuaje F 

PROVIDER: S-EPMC2836383 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature