Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.

ABSTRACT:

Objective

An inversion polymorphism of approximately 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene defines two haplotype clades, H1 and H2. Several small case-control studies have observed a marginally significant excess of the H1/H1 diplotype among patients with Parkinson's disease (PD), and one reported refining the association to a region spanning exons 1 to 4 of MAPT. We sought to replicate these findings.

Methods

We genotyped 1,762 PD patients and 2,010 control subjects for a single nucleotide polymorphism (SNP) that differentiates the H1 and H2 clades. We also analyzed four SNPs that define subhaplotypes within H1 previously reported to associate with PD or other neurodegenerative disorders.

Results

After adjusting

SUBMITTER: Zabetian CP 

PROVIDER: S-EPMC2836920 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature