Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.

ABSTRACT:

Background

Many studies of cocaine-responsive gene expression have focused on changes occurring during cocaine exposure, but few studies have examined the persistence of these changes with cocaine abstinence. Persistent changes in gene expression, as well as alterations induced during abstinence may underlie long-lasting drug craving and relapse liability.

Results

Whole-genome expression analysis was conducted on a rat cocaine binge-abstinence model that has previously been demonstrated to engender increased drug seeking and taking with abstinence. Gene expression changes in two mesolimbic terminal fields (mPFC and NAc) were identified in a comparison of cocaine-naïve rats with rats after 10 days of cocaine self-administration followed by 1, 10, or 100 days of enforced absti

SUBMITTER: Freeman WM 

PROVIDER: S-EPMC2837051 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature