Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis.

ABSTRACT: Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western societies on the basis of ginger's traditional use as an anti-inflammatory in Chinese and Ayurvedic medicine. However, scientific evidence of ginger's antiarthritic effects is sparse, and its bioactive joint-protective components have not been identified. Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives. Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more effi

SUBMITTER: Funk JL 

PROVIDER: S-EPMC2837120 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature