BTG interacts with retinoblastoma to control cell fate in Dictyostelium.

ABSTRACT:

Background

In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation. Though conceptually distinct, they are often causally related and functional interactions between the cell cycle machinery and cell fate control networks are fundamental to coordinate growth and differentiation. A switch from proliferation to differentiation may also be important in the life cycle of single-celled organisms, and genes which arose as regulators of microbial differentiation may be conserved in higher organisms. Studies in microorganisms may thus contribute to understanding the molecular links between cell cyc

SUBMITTER: Conte D 

PROVIDER: S-EPMC2837350 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature