Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.

ABSTRACT:

Background

Lung cancer is commonly treated with platinum compounds. The "glutathione pathway" participates in the metabolism of platinum compounds. We set out to test the hypotheses that single nucleotide polymorphisms (SNPs) or copy number polymorphisms for genes within the glutathione pathway might influence survival in lung cancer patients treated with these drugs.

Methods

Germline DNA samples from 973 lung cancer patients were genotyped for 290 glutathione pathway SNPs. GSTT1 copy number was also assayed. We determined the association of these polymorphisms with survival for lung cancer patients, followed by functional genomic validation.

Results

We observed suggestive associations between survival and GSTT1 copy number (P = 0.017), and GSTA5, GSTM4, and ABCC4 SNP

SUBMITTER: Moyer AM 

PROVIDER: S-EPMC2837367 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature