Deciphering normal blood gene expression variation--The NOWAC postgenome study.

ABSTRACT: There is growing evidence that gene expression profiling of peripheral blood cells is a valuable tool for assessing gene signatures related to exposure, drug-response, or disease. However, the true promise of this approach can not be estimated until the scientific community has robust baseline data describing variation in gene expression patterns in normal individuals. Using a large representative sample set of postmenopausal women (N = 286) in the Norwegian Women and Cancer (NOWAC) postgenome study, we investigated variability of whole blood gene expression in the general population. In particular, we examined changes in blood gene expression caused by technical variability, normal inter-individual differences, and exposure variables at proportions and levels relevant to real-life situati

SUBMITTER: Dumeaux V 

PROVIDER: S-EPMC2837385 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature