Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.

ABSTRACT: Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint.

SUBMITTER: Voineagu I 

PROVIDER: S-EPMC2837601 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature