Comparative evolutionary analysis of protein complexes in E. coli and yeast.

ABSTRACT:

Background

Proteins do not act in isolation; they frequently act together in protein complexes to carry out concerted cellular functions. The evolution of complexes is poorly understood, especially in organisms other than yeast, where little experimental data has been available.

Results

We generated accurate, high coverage datasets of protein complexes for E. coli and yeast in order to study differences in the evolution of complexes between these two species. We show that substantial differences exist in how complexes have evolved between these organisms. A previously proposed model of complex evolution identified complexes with cores of interacting homologues. We support findings of the relative importance of this mode of evolution in yeast, but find that it is much less co

SUBMITTER: Reid AJ 

PROVIDER: S-EPMC2837643 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature