Comparative genomics reveals selective distribution and domain organization of FYVE and PX domain proteins across eukaryotic lineages.

ABSTRACT:

Background

Phosphatidylinositol 3-phosphate is involved in regulation of several key cellular processes, mainly endocytosis, signaling, nuclear processes, cytoskeletal remodelling, cell survival, membrane trafficking, phagosome maturation and autophagy. In most cases effector proteins bind to this lipid, using either FYVE or PX domain. These two domains are distributed amongst varied life forms such as virus, protists, fungi, viridiplantae and metazoa. As the binding ligand is identical for both domains, the goal of this study was to understand if there is any selectivity for either of these domains in different taxa. Further, to understand the different cellular functions that these domains may be involved in, we analyzed the taxonomic distribution of additional domains that assoc

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC2837644 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature