Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling.

ABSTRACT: During brain development, neurons and their nerve fibers are often segregated in specific layers. The hippocampus is a well-suited model system to study lamination in health and aberrant cell/fiber lamination associated with neurological disorders. SRF (serum response factor), a transcription factor, regulates synaptic-activity-induced immediate-early gene (IEG) induction and cytoskeleton-based neuronal motility. Using early postnatal conditional SRF ablation, we uncovered distorted hippocampal lamination, including malpositioning of granule cell neurons and disruption of layer-restricted termination of commissural-associational and mossy fiber axons. Besides axons, dendrite branching and spine morphogenesis in Srf mutants were impaired, offering a first morphological basis for SRF's repor

SUBMITTER: Stritt C 

PROVIDER: S-EPMC2838085 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature