Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritis.

ABSTRACT:

Objective

Juvenile idiopathic arthritis (JIA) is a chronic autoimmune arthropathy. Beta 2-adrenergic receptors are a link between the sympathetic nervous system and the immune system. Associations between variants in the gene encoding the beta 2-adrenergic receptor (ADRB2) and autoimmune disorders such as rheumatoid arthritis (RA) have been demonstrated. We aimed to investigate ADRB2 variants for association with JIA.

Methods

Genotypes and haplotypes of two ADRB2 variants (G16R and Q27E) were determined in 348 children with JIA and 448 healthy controls by direct molecular haplotyping using melting-curve analysis of a fluorescently labelled loci-spanning probe. Case-control analysis was performed to investigate whether ADRB2 variants were associated with JIA.

Results

N

SUBMITTER: Pont-Kingdon G 

PROVIDER: S-EPMC2838190 | biostudies-literature | 2009 Mar-Apr

REPOSITORIES: biostudies-literature