P53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer.

ABSTRACT:

Background

This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer.

Methods

p53-AAb were detected by ELISA in sera obtained preoperatively from women undergoing surgery for a pelvic mass. This group included women subsequently diagnosed with invasive serous ovarian cancer (n = 60), nonserous ovarian cancers (n = 30), and women with benign disease (n = 30). Age-matched controls were selected from the general population (n = 120). Receiver operating characteristic curves were constructed to compare the values of p53-AAb, CA 125, and HE4 as a screening biomarker. Kaplan-Meier curves and Cox proportional hazards modeling were used to assess its prognostic value on survival.

Results

p53-AAb were detected

SUBMITTER: Anderson KS 

PROVIDER: S-EPMC2838192 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature