Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

ABSTRACT:

Context

Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity.

Objective

To evaluate the relationship of neuropsychological performance and white matter hyperintensity with clinical response in late-life depression.

Design

Two-site, prospective, nonrandomized controlled trial.

Setting

Outpatient clinics at Washington University and Duke University.

Participants

A total of 217 subjects aged 60 years or older met DSM-IV criteria for major depression, scored 20 or more on the Montgomery-Asberg Depression Rating Scale (MADRS), and received vascular risk factor scores, neuropsychological testing, and magnetic resonance imaging; they were excluded for cognit

SUBMITTER: Sheline YI 

PROVIDER: S-EPMC2838210 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature