Total synthesis of brevisamide.

ABSTRACT: The second total synthesis of Brevisamide, a marine cyclic ether alkaloid from Karenia brevis, is reported. This streamlined synthesis proceeds in 21 steps, 14 steps longest linear sequence, in 5.2% overall yield and features a key SmI(2) reductive cyclization step to access the tetrasubstituted pyran core.

SUBMITTER: Fadeyi OO 

PROVIDER: S-EPMC2838230 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature