Experimental and theoretical investigation of chain length and surface coverage on fouling of surface grafted polypeptoids.

ABSTRACT: Numerous strategies exist to prevent biological fouling of surfaces in physiological environments; our strategy focuses on the modification of surfaces with poly-N-substituted glycine oligomers (polypeptoids). We previously reported the synthesis and characterization of three novel polypeptoid polymers that can be used to modify titanium oxide surfaces, rendering the surfaces resistant to adsorption of proteins, to adhesion of mammalian and bacterial cells and to degradation by common protease enzymes. In this study, we investigated the effect of polypeptoid chain length on the antifouling properties of the modified surfaces. For these experiments we used poly(N-methoxyethyl) glycines with lengths between ten and fifty repeat units and determined the influence of chain length on coating th

SUBMITTER: Statz AR 

PROVIDER: S-EPMC2838250 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature