Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.

ABSTRACT:

Context

The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes beta-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD).

Objective

To relate baseline circulating leptin concentrations in a community-based sample of individuals without dementia to incident dementia and AD during follow-up and magnetic resonance imaging (MRI) measures of brain aging in survivors.

Design, setting, and participants

Prospective study of plasma leptin concentrations measured in 785 persons without dementia (mean [SD] age, 79 [5] years; 62% female), who were in the Framingham original cohort at the 22nd examination cycle (1990-1994). A subsample of 198 dementia-free survivors underwent volu

SUBMITTER: Lieb W 

PROVIDER: S-EPMC2838501 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature