Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils.

ABSTRACT:

Background

Lung cancer often develops in association with chronic pulmonary inflammatory diseases with an influx of neutrophils. More detailed information on inflammatory pathways and the role of neutrophils herein is a prerequisite for understanding the mechanism of inflammation associated cancer.

Methods

In the present study, we used microarrays in order to obtain a global view of the transcriptional responses of the lung to LPS in mice, which mimics an acute lung inflammation. To investigate the influence of neutrophils in this process, we depleted mice from circulating neutrophils by treatment with anti-PMN antibodies prior to LPS exposure.

Results

A total of 514 genes was greater than 1.5-fold differentially expressed in the LPS induced lung inflammation model. 3

SUBMITTER: Gungor N 

PROVIDER: S-EPMC2838834 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature